Ageing: Repair and Transcription Keep Us from Premature Ageing
نویسنده
چکیده
Trichothiodystrophy (TTD) is a complex disorder caused by mutations in the XPD gene which affect both DNA repair and transcription. A mouse with a TTD mutation has now been found to display remarkable signs of premature ageing.
منابع مشابه
Effects of Drought Stress during Seed Development and Subsequent Accelerated Ageing on Wheat Seed Mitochondrial Ultra-structure, Seedling Antioxidant Enzymes, and Malondialdehyde
In this experiment, wheat plants were exposed to drought stress during seed development then we worked on the obtained seeds. The seed mitochondrial ultra-structure, and antioxidant enzymes in seedling were investigated after exposure to seed accelerated ageing. Drought stress during seed development induced some changes in mitochondrial ultra-structure. Encountering seed development to drought...
متن کاملEffects of Drought Stress during Seed Development and Subsequent Accelerated Ageing on Wheat Seed Mitochondrial Ultra-structure, Seedling Antioxidant Enzymes, and Malondialdehyde
In this experiment, wheat plants were exposed to drought stress during seed development then we worked on the obtained seeds. The seed mitochondrial ultra-structure, and antioxidant enzymes in seedling were investigated after exposure to seed accelerated ageing. Drought stress during seed development induced some changes in mitochondrial ultra-structure. Encountering seed development to drought...
متن کاملA review and appraisal of the DNA damage theory of ageing.
Given the central role of DNA in life, and how ageing can be seen as the gradual and irreversible breakdown of living systems, the idea that damage to the DNA is the crucial cause of ageing remains a powerful one. DNA damage and mutations of different types clearly accumulate with age in mammalian tissues. Human progeroid syndromes resulting in what appears to be accelerated ageing have been li...
متن کاملXeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients.
A workshop(1) to share, consider and discuss the latest developments in understanding xeroderma pigmentosum and other human diseases caused by defects in nucleotide excision repair (NER) of DNA damage was held on September 21-24, 2010 in Virginia. It was attended by approximately 100 researchers and clinicians, as well as several patients and representatives of patient support groups. This was ...
متن کاملMandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing
Mandibuloacral dysplasia (MAD) is a rare genetic condition characterized by bone abnormalities including localized osteolysis and generalized osteoporosis, skin pigmentation, lipodystrophic signs and mildly accelerated ageing. The molecular defects associated with MAD are mutations in LMNA or ZMPSTE24 (FACE1) gene, causing type A or type B MAD, respectively. Downstream of LMNA or ZMPSTE24 mutat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002